Clinical Guidance and Documentation
The Yorkshire and Humber Children’s, Teenage and Young Adult Cancer Clinical Network meets quarterly with representatives present from each centre in the network. Matters arising, service updates and project progress is amongst the discussion topics.
The network board meets annually to discuss upcoming workstreams and any high-level needs and changes within the network.
Key Clinical Guidance
Leeds Principal Treatment Centres and Paediatric Oncology Shared Care Units (Airedale, Calderdale and Huddersfield, Hull, and York and Scarborough)
Central Line Care
- Central Venous Catheter Infection for Infants (Excluding Neonates on the NICU) and Children
- Central Venous Catheters in Adults and Children
Febrile Neutropenia
Transfusion
Mouthcare/Mucositis
- Mucositis and the Promotion of Oral Health in Children and Young People With Malignant Disease
- Cryotherapy as Prophylaxis of Mucositis in Children and Adolescents with Cancer and Paediatric Hematopoietic Stem Cell Transplant Recipients (HSCT) who Receive Short Infusions of Chemotherapy
Photobiomodulation for prevention of oral mucositis in children and young people undergoing chemotherapy
Nausea and vomiting
Constipation
Analgesia
SACT administration guidelines
- Awaiting sign off
Pneumocystis
New patient investigations
Tumour Lysis Syndrome
Spinal Cord Compression
Raised intracranial pressure
Sheffield Principal Treatment Centres and Paediatric Oncology Shared Care Unit (North Lincolnshire and Goole)
All the guidance listed below can be accessed here: https://www.sheffieldchildrens.nhs.uk/services/haematology-oncology/shared-care-guidelines/
Central Line Care
Febrile Neutropenia
Chemotherapy in the home
Transfusion
Mouthcare
Nausea and vomiting
Diarrhoea
Constipation
Analgesia
Nutrition
All the guidance listed below can be accessed here: https://www.sheffieldchildrens.nhs.uk/services/haematology-oncology/shared-care-guidelines/
Tumour Lysis Syndrome
Spinal Cord Compression
Raised intracranial pressure
Mediastinal Mass
- Links to guidance and referrals coming soon.
High WCC leukaemia
- Links to guidance and referrals coming soon.
Network Documentation
Yorkshire and Humber Cancer Clinical Network was previously known as Operational Delivery Network (ODN), therefore the title is present in documentation prior to 2024.
Children’s Network Meetings
17.01.2024
   Children's Cancer Clinical Network Meeting Agenda
   Children's Cancer Clinical Network Meeting Minutes
17.04.2024
   Children's Cancer Clinical Network Meeting Agenda
   Children's Cancer Clinical Network Meeting Minutes
10.07.2024
   Children's Cancer Clinical Network Meeting Agenda
   Children's Cancer Clinical Network Meeting Minutes
25.01.2023
   Children's ODN Meeting Agenda
   Children's ODN Meeting Minutes
19.04.2023
   Children's ODN Meeting Agenda
   Children's ODN Meeting Minutes
19.07.2023
   Children's ODN Meeting Agenda
   Children's ODN Meeting Minutes
18.10.2023
   Children's ODN Meeting Agenda
   Children's ODN Meeting Minutes
26.01.2022
   Children's ODN Meeting Agenda
   Children's ODN Meeting Minutes
26.04.2022
   Children's ODN Meeting Agenda
   Children's ODN Meeting Minutes
13.07.2022
   Children's ODN Meeting Agenda
   Children's ODN Meeting Minutes
04.10.2022
   Children's ODN Meeting Agenda
   Children's ODN Meeting Minutes
Teenage and Young Adult Network Meetings
30.03.2023
   TYA ODN Meeting Agenda
   TYA ODN Meeting Minutes
06.06.2023
   TYA ODN Meeting Agenda
   TYA ODN Meeting Minutes
05.12.2023
   TYA ODN Meeting Agenda
   TYA ODN Meeting Minutes
03.03.2022
   TYA ODN Meeting Agenda
   TYA ODN Meeting Minutes
06.06.2022
   TYA ODN Meeting Agenda
   TYA ODN Meeting Minutes
14.09.2022
   TYA ODN Meeting Agenda
   TYA ODN Meeting Minutes
02.12.2022
   TYA ODN Meeting Agenda
   TYA ODN Meeting Minutes
24.11.2021
   TYA ODN Meeting Agenda
   TYA ODN Meeting Minutes
Cancer Clinical Network Board Meetings
31.05.2022
   ODN Board Meeting Agenda
   ODN Board Meeting Minutes
29.11.2022
   ODN Board Meeting Agenda
   ODN Board Meeting Minutes
Service specifications
Newsletters
   October Newsletter
Whole Genome Sequencing (WGS)
Tasha Morley (Genomic Nurse Practitioner, North and East Yorkshire Genomics Lab Hub) has devised a useful guide containing guidance and resources for WGS.
WGS (Whole Genome Sequencing)
What can a whole genome sequencing test tell you? Even though the whole genome sequencing test looks at your whole genome, the test is focused on changes in genes related to cancer; it is not looking for changes in genes that cause other conditions.
The results take approximately 6 months to be discussed at a regional genomic meeting, which is attended by scientists, clinicians, and pathologists within the region.
The meeting discusses if the results correlate to the disease, if any academic papers relate to the information any research trials that linked to the results and if a clinical genetics referral needs to be made.
Please note that the test could fail to produce any actionable clinical information or could fail at some point through the process of obtaining the results.
For WGS test to be offered and be completed
Suspected solid tumour patient
 FRESH sample of suspected tumour tissue needs to be sent to pathology.
25mm> or more (pathologist needs to check cellularity, tumour content)
North-east-and-Yorkshire-sample-requirements-for-whole-genome-sequencing.pdf (ney-genomics.org.uk) see end of eligibility for sample requirements.
 Biopsy 16 Gauge or 18 Gauge, request extra 2 FRESH samples from the radiologist.
A bigger gauge with smaller sample is less likely to produce a successful result.
Haematology patient except Lymphoma
 Bone marrow aspirate sample needs to be requested to go to HODS/HMDS within 72 hours of BMA (Bone Marrow Aspirate).
 NEY-GLH-HaemOnc-WGS-Eligibilty-Nov-2021.pdf (ney-genomics.org.uk)
For ALL WGS Patients
 PIS patient information genome-sequencing-cancer-patient-information-easy-read.pdf (england.nhs.uk), genome-sequencing-cancer-patient-information.pdf (england.nhs.uk) & Taking part | Genomics England
 Do Record of Discussion (ROD) – please ensure that there is good understanding of all statements, that the test is optional, the research part can be withdrawn from, and the form can be accessed from Genomics England WGS documentation.
 England » Genomics resources – ROD form link
 Email ROD to local Genetics labs -
Sheffield - [email protected]
Leeds - [email protected]
 When emailing the ROD cc, the pathologist so the frozen sample is sent to the genetics labs.
 Photocopy ROD form, give copy to patient, put in medical notes, and safely store hard copy.
 Suspected Solid tumour patient – For Germline - Full EDTA Genetics labs (Sheffield Children Hospital or Leeds Genetics Lab) – with TOF (test order form)
 Suspected haematology germline requires a skin biopsy FRESH (solution N/saline or HUM 1) send to local genetics labs within 72 hours.
 NHS England » ¬Genomics resources - Must have test order form (TOF) form attached with germline.
Resources and useful Links
Helpful resources
Teenage and Young Adults
Fertility preservation options for males and females
- Links to guidance and referrals coming soon.
Sexual health advice (including contraception) prior to treatment
- Links to guidance and referrals coming soon.
Transition
- Links to guidance and referrals coming soon.
TYA PTC MDT Referral Form
Links to guidance and referrals coming soon.
Late Effects Referral Form
Links to guidance and referrals coming soon.